Researchers hope to determine if fasudil improves brain health and prevents cognitive decline.

Discovery could explain failed clinical trials for Alzheimer’s, and provide a solution

Researchers have discovered a vicious feedback loop underlying brain degeneration in Alzheimer’s disease which may explain why so many drug trials have failed.

The study also identifies a clinically approved drug which breaks the vicious cycle and protects against memory-loss in animal models of Alzheimer’s.

Overproduction of the protein beta-amyloid is strongly linked to development of Alzheimer’s disease but many drugs targeting beta-amyloid have failed in clinical trials. Beta-amyloid attacks and destroys synapses – the connections between nerve cells in the brain – resulting in memory problems, dementia and ultimately death.

The new study, involving the University of Exeter and led by King’s College London, is published today in Translational Psychiatry. The researchers found that when beta-amyloid destroys a synapse, the nerve cells make more beta-amyloid driving yet more synapses to be destroyed.

“We show that a vicious positive feedback loop exists in which beta-amyloid drives its own production,” says senior author Dr Richard Killick from King’s College London. “We think that once this feedback loop gets out of control it is too late for drugs which target beta-amyloid to be effective, and this could explain why so many Alzheimer’s drug trials have failed.”

Co-author Clive Ballard, Professor of Age-Related Disease at the University of Exeter Medical School, said: “These fascinating results raise the prospect for fasudil to improve brain health and prevent cognitive decline. It’s already used in Japan to treat pulmonary hypertension, and it’s well tolerated. We now need to move this forward to a clinical trial in people with Alzheimer’s disease as soon as possible. We’ll do so through our innovative phase 2 trials platform designed to accelerate discovery of effective treatment in dementia.”

“Our work uncovers the intimate link between synapse loss and beta-amyloid in the earliest stages of Alzheimer’s disease,” says lead author Dr Christina Elliott from King’s College London. “This is a major step forward in our understanding of the disease and highlights the importance of early therapeutic intervention.”

The researchers also found that a protein called Dkk1, which potently stimulates production of beta-amyloid, is central to the positive feedback loop. Previous research by Dr Killick and colleagues identified Dkk1 as a central player in Alzheimer’s, and while Dkk1 is barely detectable in the brains of young adults its production increases as we age.

Instead of targeting beta-amyloid itself, the researchers believe targeting Dkk1 could be a better way to halt the progress of Alzheimer’s disease by disrupting the vicious cycle of beta-amyloid production and synapse loss.

“Importantly, our work has shown that we may already be in a position to block the feedback loop with a drug called fasudil which is already used in Japan and China for stroke.” says Dr Killick. “We have convincingly shown that fasudil can protect synapses and memory in animal models of Alzheimer’s, and at the same time reduces the amount of beta-amyloid in the brain.”

The researchers found that in mice engineered to develop large deposits of beta-amyloid in their brains as they age, just two weeks of treatment with fasudil dramatically reduced the beta-amyloid deposits.

Researchers at King’s College London are now seeking funding to run a trial in early stage sufferers of Alzheimer’s to determine if fasudil improves brain health and prevents cognitive decline.

Professor Dag Aarsland from the IoPPN said “As well as being a safe drug, fasudil appears to enter the brain in sufficient quantity to potentially be an effective treatment against beta-amyloid. We now need to move this forward to a clinical trial in people with early stage Alzheimer’s disease as soon as possible.”

The research was funded by the Medical Research Council.

The paper, A role for APP in Wnt signalling links synapse loss with β-amyloid production, is published in Translational Psychiatry.

To find out more about dementia research at Exeter, follow #ExeterDementia on Twitter or visit our dementia website: http://www.exeter.ac.uk/dementia/.

Date: 20 September 2018