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EPSRC Hub for Quantitative Modelling in Healthcare news archive: 2021-2022

Domino cascade

Initial plan for the domino cascade

Dr Jen Creaser explains seizure onset in epilepsy

"The Domino Effect in Seizure Onset in Epilepsy” available here: https://www.youtube.com/watch?v=D98HH-n5Goc&t=1s

As a researcher in mathematical neuroscience at the University of Exeter Jen uses mathematics to understand the behaviour of the brain. She is interested in how the brain functions when someone is healthy and what happens when someone has a neurological disorder such as epilepsy.  To do this, she thinks of the brain as a group of different regions that are joined together in a network. These regions are constantly communicating with each other using electricity.  When someone has epilepsy, they can have large bursts of electrical activity (like a power surge) in the brain that cause seizures. This brain activity can be recorded on the scalp. These recordings are important as they are used by doctors to diagnose and treat epilepsy. The recordings contain lots of different patterns when the brain switches from resting activity to seizure activity, some of which make diagnosis really hard.